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News & Publications

Clark develops biochip to detect toxicity without animal testing
http://www.berkeley.edu/news/media/releases/2007/12/18_datachip.shtml

Move over, Cal Band! The marching cells are here
http://www.berkeley.edu/news/media/releases/2007/11/09_cells.shtml

Mathies makes a big splash with one drop of wine
http://chemistry.berkeley.edu/Publications/news/2007/mathies_wine_amines.html

CBGP student Albers wins ACS organic chemistry fellowship
http://chemistry.berkeley.edu/Publications/news/2007/albers_acs_fellowship.html

Michelle Chang wins New Faculty Award
http://chemistry.berkeley.edu/Publications/news/2007/chang_dreyfus_award.html

Two grad students earn ACS medicinal chemistry fellowships
http://chemistry.berkeley.edu/Publications/news/2007/acs_award.html

Schaffer wins $2.1 million stem cell research grant
http://chemistry.berkeley.edu/Publications/news/2007/schaffer_stem_cell_research_grant.html

Sarpong wins young investigator awards from Amgen, Abbott
http://chemistry.berkeley.edu/Publications/news/2007/sarpong_award.html

Two grad students earn ACS medicinal chemistry fellowships
http://chemistry.berkeley.edu/Publications/news/2007/acs_award.html

Doudna and Bertozzi Receive Gift from Gilead Sciences
http://ls.berkeley.edu/?q=node/499

Thorner elected to the American Academy of Arts and Sciences
http://www.berkeley.edu/news/media/releases/2007/04/30_aaas.shtml

Rebecca Heald Receives NIH Pioneer Award
http://www.berkeley.edu/news/media/releases/2006/09/20_pioneer.shtml

Student Publications

  1. Fraser, C.S.; Berry, K.E.; Hershey J.W.; Doudna, J.A. "eIF3j is Located in the Decoding Center of the Human 40S Ribosomal Subunit." Mol Cell. 2007. 26, 811-9.
  2. Blair, J.A.; Rauh, D.; Kung, C.; Yun, C.H.; Fan, Q.W.; Rode, H.; Zhang, C.; Eck, M.J.; Weiss, W.A.; Shokat, K.M. "Structure guided development of affinity probes for tyrosine kinases using
    chemical genetics." Nat. Chem. Biol. 2007. 3, (4), 229-38.
  3. Sergina, N.V.; Rausch, M.; Wang, D.; Blair, J.; Hann, B.; Shokat, K.M.; Moasser, M.M. "Escape from HER–family tyrosine kinase inhibitor therapy by the kinase–inactive HER3." Nature. 2007. 445, (7126), 437-41.
  4. Laughlin, S. T.; Bertozzi, C. R. "Metabolic Labeling of Glycans with Azido Sugars and Subsequent Glycan-profiling and Visualization via Staudinger Ligation". Nature Protocols. 2007, 11, 2930-2944.
  5. Baskin, J. M.; Prescher, J. A.; Laughlin, S. T.; Agard, N. J.; Chang, P. V.; Miller, I. A.; Lo, A.; Codelli, J.A.; Bertozzi, C. R. "Copper-Free Click Chemistry for Dynamic In Vivo Imaging". Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 16793-7.
  6. Douglas, E. S.; Chandra, R. A.; Bertozzi, C. R.; Mathies, R. A.; Francis, M. B. "Self-assembled Cellular Microarrays Patterned Using DNA Barcodes". Lab Chip 2007, 7, 1442-8.
  7. Hanson, J.A.; Duderstadt, K.; Watkins, L.P.; Bhattacharyya, S.; Brokaw, J.; Chu, J.-W.; Yang, H. "Illuminating the Mechanistic Rols of Enzyme Conformational Dynamics." Proc. Natl. Acad. Sci.
    U.S.A. 2007. 104, 18055-60.
  8. Harvey, J.H.; Butler, B.K.; Trauner, D. "Functionalized azobenzenes through cross-coupling with organotrifluoroborates." Tet. Lett. 2007. 48, 1661.
  9. Kovacs, E.W.; Hooker, J.M.; Romanini, D.W.; Holder, P.G.; Berry, K.E.; Francis, M.B. "Dual-Surface Modified Bacteriophage MS2 as an Ideal Scaffold for a Viral Capsid-Based Drug Delivery System." Bioconjugate Chem. 2007. 18 (4), 1140 -47.
  10. Martin, N.I. Woodward, J.J., Winter, M.B., Beeson, W.T. and Marletta, M.A. "Design and synthesis of C5 methylated L-arginine analogues as active site probes for nitric oxide synthase". J. Amer. Chem. Soc. 129: 12563-12570. (2007).
  11. Miller, E. W.; Bian, S. X.; Chang, C. J. "A Fluorescent Sensor for Imaging Reversible Redox Cycles in Living Cells", J. Am. Chem. Soc. 2007, 129, 3458-9.
  12. Miller, E. W.; Tulyathan, O.; Isacoff, E. Y.; Chang, C. J. "Molecular Imaging of Hydrogen Peroxide Produced for Cell Signaling", Nature Chemical Biology 2007, 3, 263-7.
  13. Yoon, S.; Miller, E. W.; He, Q.; Do, P. H.; Chang, C. J. Angew. "A Bright and Specific Fluorescent Sensor for Mercury in Water, Cells, and Tissue." Chem. Int. Ed. Engl. 2007, 46(35), 6658-61.
  14. Albers, A.; Rawls, K. A.; Chang, C. Chem. Commun. 2007, DOI:10.1039/b713190a.
  15. Soellner, M. B.; Rawls, K. A.; Grundner, C.; Alber, T.; Ellman, J. A. J. Am. Chem. Soc. 2007,
    129, 9613-9615.
  16. Volgraf, M.; Gorostiza, P.; Szobota, S.; Helix, M.R.; Isacoff, E.Y.; Trauner, D. "Reversibly Caged Glutamate: A Photochromic Agonist of Ionotropic Glutamate Receptors." J. Am. Chem. Soc. 2007, 129 (2), 260-261.
  17. Gorostiza, P.; Volgraf, M.; Numano, R.; Szobota, S.; Trauner, D.; Isacoff, E.Y. "Engineering a Channel Protein for Remote Control: Mechanisms of Photoswitch Conjugation and Light Activation of an Ionotropic Glutamate Receptor." Proc. Natl. Acad. Sci. USA 2007, 104 (26), 10865-10870.
  18. Szobota, S.; Gorostiza, P.; Del Bene, F.; Wyart, C.; Fortin, D.L.; Kolstad, K.D.; Tulyathan, O.; Volgraf, M.; Numano, R.; Aaron, H.L.; Scott, E.K.; Kramer, R.H.; Flannery, J.; Baier, H.; Trauner, D.; Isacoff, E. "Remote Control of Neuronal Activity with a Light-Gated Glutamate Receptor." Neuron 2007, 54 (4), 535-545.
  19. Volgraf, M.; Gorostiza, P.; Numano, R.; Kramer, R.H.; Isacoff, E.Y.; Trauner. D. "Allosteric Control of an Ionotropic Glutamate Receptor with an Optical Switch." Nature Chem. Biol. 2006, 2 (1), 47-52 (Cover Article).
  20. Banghart, M.R.; Volgraf, M.; Trauner, D. "Engineering Light-Gated Ion Channels." Biochemistry 2006, 45 (51), 15129-15141.
  21. Rush J, Bertozzi CR. An alpha-formylglycine building block for fmoc-based solid-phase peptide synthesis. Org Lett. 2006 Jan 5;8(1):131-4.
  22. Mitchell, D.A., Fernhoff, N., Morton, S.U. and Marletta, M.A. "Thioredoxin is Required for S-Nitrosation of Procaspase-3 and the Inhibition of Apoptosis in Jurkat Cells". Proc. Natl. Acad. Sci USA 104: 11609-11614. (2006).
  23. Mitchell, D.A., Morton, S.U. and Marletta M. A. "Design and characterization of an active site selectivecaspase-3 transnitrosating agent". ACS Chemical Biology 1:659-665. (2006).
  24. Erwin P.A., Mitchell D.A., Sartoretto J., Marletta M.A. and Michel T. "Subcellular targeting and differential S-nitrosylation of endothelial nitric-oxide synthase". J. Biol. Chem. 281: 151-157. (2006).
  25. Laughlin, S. T.; Agard, N. J.; Baskin, J. M.; Carrico, I. S.; Chang, P. V.; Ganguli, A. S.; Hangauer, M. J.; Lo, A.; Prescher, J. A.; Bertozzi, C. R. "Metabolic Labeling of Glycans with Azido Sugars for Visualization and Glycoproteomics". Methods Enzymol. 2006, 415, 230-250.
  26. Agard, N. J.; Baskin, J. M.; Prescher, J. A.; Lo, A.; Bertozzi, C. R. A Comparative Study of Bioorthogonal Reactions with Azides. ACS Chem. Biol. 2006, 1, 644-8.
  27. Rabuka, D.; Hubbard, S. C.; Laughlin, S. T.; Argade, S. P.; Bertozzi, C. R. "A Chemical Reporter Strategy to Probe Glycoprotein Fucosylation." J. Am. Chem. Soc. 2006, 128, 12078-9.
  28. Link, A. J.; Vink, M. K.; Agard, N. J.; Prescher, J. A.; Bertozzi, C. R.; Tirrell, D. A. "Discovery of Aminoacyl-tRNA Synthetase Activity Through Cell Surface Display of Noncanonical Amino Acids". Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 10180-5.

Trainee Talks and Posters

  1. Blair, Jimmy. "Carleton College Chemistry Department Seminar." Carleton College, Northfield, MN. November 2, 2007 (Talk).
  2. Volgraf, M.; Szobota, S.; Gorostiza, P.; Wyart, C.; Isacoff, E.Y.; Trauner, D. "Photocontrol of Ionotropic Glutamate Receptors: From Design to in vivo Application." ACS National Meeting, Medicinal Chemistry Division Predoctoral Fellowship Award Symposium. Boston, MA. September
    2007 (Talk).
  3. Chang, HH; Falick, AM; Carlton, PM; Sedat, JW; DeRisi, JL; and Marletta, MA. "N-Terminal
    Processing of Proteins Exported by Malaria Parasites". 2007 Molecular Parasitology Meeting (MPMXVIII), Woods Hole, Massachussetts, September 2007. (award winning poster).
  4. Hatzios, Stavroula, "Defining the role of the phosphatase CysQ in mycobacterial sulfate metabolism." Research Conference on TB Drug Development. Magdalen College, Oxford University, Oxford, England. August 26-31, 2007 (poster).
  5. Romanini, DW; Hooker, JM; O'Neil, JP; Francis, MB. "Virus capsid-based materials for medical imaging." 234th ACS National Meeting, Boston, MA. August 23, 2007 (Talk).
  6. Hanson, Jeff. "Single-molecule conformational dynamics of E. coli adenylate kinase." ACS National Meeting. Boston, MA. August, 21 2007 (Talk).
  7. Bell, S.C.; Kohout, S.C.; Isacoff E.Y. "Electrophysiological and optical study of the voltage-gated phosphatase Ci-VSP." 2007 Chemical Biology Interface Training Summit, National Institutes of Health. Bethesda, MD. June 20-22, 2007 (Talk).
  8. Berry, Katie. "Investigating mRNA Recruitment by the Human Ribosome using Fluorescence Spectroscopy." Nucleic Acids Gordon Conference. Boston, MA. June 2007 (Talk).
  9. Volgraf, M.; Szobota, S.; Gorostiza, P.; Wyart, C.; Isacoff, E.Y.; Trauner, D. "Photocontrol of Ionotropic Glutamate Receptors: From Design to in vivo Application." Roche Excellence in Chemistry Award Symposium. Nutley, NJ. June 2007 (Talk).
  10. Witus, Leah. "Peptides that non-covalently functionalize carbon nanotubes." Materials Research Society Meeting. San Francisco, CA. Spring 2007 (Talk).
  11. Bell, S.C.; Kohout, S.C.; Ulbrich, M.H.; Isacoff, E.Y. "Optical and Electrophysiological Study of CiVSP Assembly and Activity." 51st Annual Meeting of the Biophysical Society. Baltimore, MD. March 3-7, 2007 (Talk).
  12. Berry, Katie. "Probing Pre-Initiation Interactions in the 40S Ribosome mRNA Binding Cleft, Translation Supergroup." UC Berkeley, Stanford, UC Davis. Berkeley, CA. November 2006 (Talk).
  13. Holder, Patrick G. 232nd Annual ACS Conference. San Francisco, CA. September 10-14, 2006 (Talk).
  14. Volgraf, M.; Gorostiza, P.; Szobota, S.; Numano, R.; Kramer, R.H.; Isacoff, E.Y.; Trauner, D. "Photocontrol of Ionotropic Glutamate Receptors: New Tools for Chemical Neurobiology." ACS National Meeting. San Francisco, CA. September 2006 (Talk).
  15. Harvey, J. H.; Trauner, D. "Photocontrol of Enzyme Affinity." ACS National Meeting. San Francisco, CA. 2006 (Poster).